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Antitumor and immunomodulatory activity of a polysaccharide from fungus Coprinus comatus (Mull.:Fr.) Gray.
Jiang, Xiao-Gang; Lian, Ming-Xue; Han, Yan; Lv, She-Min.
Affiliation
  • Jiang XG; Department of Genetics and Molecular Biology, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi 710061, PR China.
Int J Biol Macromol ; 58: 349-53, 2013 Jul.
Article in En | MEDLINE | ID: mdl-23603082
In our study, a water-soluble polysaccharide (CCPa-1) was successfully purified from the fruiting bodies of Coprinus comatus by DEAE-cellulose and Sepharose CL-6B column chromatography. The molecular weight was evaluated to be 53.6 kDa as determined by high performance size exclusion chromatography (HPSEC). Sugar composition analysis revealed that CCPa-1 consisted primarily of galactose, glucose and arabinose in a molar ratio of 6.6:1.2:2.2. CCPa-1 could not only inhibit the growth of sarcoma 180 (S180) tumor transplanted in mice, but also increase the relative spleen/thymus indexes and body weight of tumor bearing mice. Moreover, Con A- or LPS-induced splenocyte proliferation was also enhanced after CCPa-1 administration in tumor-bearing mice. Furthermore, CCPa-1 significantly enhanced the Con A- or LPS-induced splenocyte proliferation and increased the production of TNF-α and IL-2. All the data demonstrated that CCPa-1 had a potential application as natural antitumor agent with immunomodulatory activity.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Coprinus / Fungal Polysaccharides / Immunologic Factors / Antineoplastic Agents Limits: Animals Language: En Journal: Int J Biol Macromol Year: 2013 Document type: Article Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Coprinus / Fungal Polysaccharides / Immunologic Factors / Antineoplastic Agents Limits: Animals Language: En Journal: Int J Biol Macromol Year: 2013 Document type: Article Country of publication: